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KMID : 0358419940370102047
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Korean Journal of Obstetrics and Gynecology
1994 Volume.37 No. 10 p.2047 ~ p.2052
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Treatment of Endometriosis with a Nasal GnRH Agonist(Nafarelin Acetate)
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전대준
고준성/이주학/정동근/남주현/목정은
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Abstract
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To evaluate the efficacy and safety of nafarelin for the treatment of endometriosis, twenty women with laparoscopically proven endometriosis were recruited to the study. The patient were treated with intranasal nafarelin, 400μg/day(200μg twice
a
day)
for 6 months. Efficacy assessments were based on preadmission and end-of treatment laparoscopic scores and subjective symptom scores at admission and end-f treatment. Safety was evaluated by adverse events.
@ES We observed following results.
@EN 1. Serum estradiol levels and serum CA-125 levels significantly fell during the treatment.
2. The endometriosis scores significantly decreased after treatment.
3. S mptoms of endometriosis significantly improved during treatment.
4. There was none of patients interrupted during treatment due to adverse effects.
These data suggest that intranasal GnRH agonist, nafarelin, nafarelin is a effective and convenient approach to the medical treatment of endometriosis.
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KEYWORD
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